Clinical study of non-invasive bi-level positive pressure ventilation for acute exacerbation of chronic obstructive pulmonary disease patients with Type II respiratory failure

Objective To study the effect of non-invasive bi-level positive pressure ventilation for acute exacerbation of chronic obstructive pulmonary disease patients with type Ⅱ respiratory failure.Methods A total of 46 AECOPD patients with type Ⅱ respiratory failure were divided into two groups.Treatment group included 23 patients were given routine therapy and non-invasive bi-level positive pressure ventilation;Control group included 23 patients were only given routine therapy.Observations of the clinical indicators of the arterial blood gas analysis,invasive ventilation rate,mortality and hospitalization days were made before and after the treatment at 1 h,4 h,24 h,48 h.Results PaO2 increased and PaCO2 decreased more significantly in treatment group comparing to the control group,and invasive ventilation,the rate of mortality and hospitalization were all lower in the treatment group than in the control group.Conclusion Non-invasive bi-level positive pressure ventilation in the treatment of AECOPD patients with type Ⅱ respiratory failure is better than that of the conventional treatment method,and can be faster,better for improving the patient's condition,and can reduce invasive ventilation rate,mortality rate and hospital stay.