Clinical Features and Prognoses of Decompensated Liver Cirrhosis of Hepatitis B with Different Viral Loads

Objective To analyze the clinical features and prognoses of decompensated liver cirrhosis of hepatitis B with different viral loads.Methods A total of 183 patients with decompensated liver cirrhosis of hepatitis B admitted from January 2008 to January 2011 were divided,according to serum hepatitis B virus(HBV) DNA level,into groups low-load(n=67,105 copies/ml)and high-load(n=116,≥105 copies/ml).Symptomatic and supportive treatment and antiviral therapy were given.The clinical data were analyzed retrospectively and the outcome recorded.Results There was no significant difference in gender,age,Child-Pugh degree of liver function between the two groups(P0.05);There was in the positive rate of HBV surface antigens(HBsAg)(P0.05).Before treatment,there was difference in aspartate aminotransferase(AST),prothrombin time(PT)(P0.05),but there was no in alanine aminotransferase(ALT),albumen(ALB),total bilirubin(TBiL),cholinesterase(CHE),total bile acid(TBA)(P0.05).After treatment,there was no difference in above-mentioned indicators(P0.05).There was difference in all observed indicators between pre-and post-treatment in the two groups(P0.05).No significant difference was noted in death rate between the two groups(χ2=0.067,P=0.796),there was difference in incidence of primary liver cancer(χ2=8.457,P=0.004),spontaneous peritonitis(χ2=20.461,P=0.000),alimentary tract hemorrhage(χ2=85.331,P=0.000).Conclusion Serum HBV DNA level can not reflect directly the condition of patients with hepatitis B decompensated liver cirrhosis.Early treatment for patients with low viral load should be paid attention to and antiviral drugs be used positively.