2009•Unpublished venueRequires access

Expression and Significance of Hypoxia-inducible Factor 2α in Ovarian Epithlial Cancer

Tianru Yang

Abstract

Objective To investigate the expression and significance of hypoxia-inducible factor 2α in ovarian epithelial cancer. Methods The expression of HIF-2α was detected by immunohistochemical technique of SP in 86 ovarian epithelial cancer and 30 normal ovaries. Results The expression rate of HIF-2α in ovarian epithelial cancer was significantly higher than that in normal ovaries(P0.05.The positivity rates of HIF-2α were closely related with clinical stages and pathological grades. Conclusion HIF-2α is overepressed in ovarian epithelial cancer and it may be used as a potential diagnostic and prognostic marker.

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Key concepts: Immunohistochemistry, Ovarian cancer, Pathological, Hypoxia-inducible factors, Hypoxia (environmental), Pathology, Clinical significance, Epithelial ovarian cancer