The Effect of Ginkgo on Interleukin4(IL-4) and Interleukin5(IL-5) in Serum of Asthmatic mice

Objective To observe the effect of Ginkgo on IL-4,IL-5 in serum of asthmatic mice. Methods 40 mouse were randomly divided into three groups(control group, sensitization group, and therapeutic group). The mouse asthmatic models were established by sensitizing with aerosolized ovalbumin(OVA). IL-4,IL-5 in serum in 16 sensitization mouse and 8 control mouse were measured by ELISA, respectively. We injected 0.15ml Ginkgo solution in the abdominal cavity of 16 therapeutic mouse before the episode of asthma. After that, they were challenged with aerosolized OVA and IL-4,IL-5 in serum were measured by ELISA. Results The levels of IL-4,IL-5 in serum in control group were (12.965±2.450)pg/ml, (13.398±4.460)pg/ml, respectively, (16.889±4.835)pg/ml, (19.471±7.207)pg/ml in sensitization, (13.695±4.068)pg/ml, (14.774±5.749)pg/ml in therapeutic group. In the sensitization group, the levels of IL-4,IL-5 in serum were higher than those of the control group( P 0.05). The level of IL-4,IL-5 in serum in therapeutic were lower than those of the sensitization group( P 0.05). Conclusion These results suggest that the Ginkgo injection can significantly reduce the level of IL-4,IL-5 in serum of sensitization mice, and it is a kind of better Chinese Herbal on anti-asthma, it even reduce level of IL-4,IL-5 in serum in sensitization reaction. It also can be some effection on Ⅱ T-helper lymphocyte in asthma.