Significance of expression of CD9 with breast carcinomas

Objective To investigate the expression of motility-related protein-1(MRP-1,CD9in breast carcinomas and the relaˉtionship between it's expression and the histopathological characteristics and prognosis of breast carcinomas.Methods Immunohistochemical method(S-P)was used to examine the expression of CD9proteins in paraffin-embedded specimens of106cases of breast carcinomas.Results Expression of CD9in106cases of breast carcinomas were different.29.2%(31.106)were positive,31.1%(33.106)were weak positive,and29.3%(31.106)were negative.Loss.reduc of CD9expression was closely correlated with histologic grades and clinic stages of breast carcinoˉma,but not with5-year revival rates(P0.05,P0.01respectively).In patients who received regular chemotherapy,the5-year revivˉal rates of the positive expression of CD9was higher than the negative expression of CD9(P0.05).Conclusions Loss.reduce of CD9exˉpression is not an independent prognostic factor for predicting progression of breast carcinomas,but can be as an indictor of chemotherapy to the post-operation patiens.