Application of cystatin C in diagnosing renal disease

Objective To study the clinical application of serum cystatin C(CysC) in diagnosis of renal disease. Method Serum CysC, Creatinine of serum and urine, Urea, Creatinine, Creatinine clearance rate(Ccr) and urinary albumin (Ualb), Urinarylobulin( of 60 patients were assayed and compared with those of 30 healthy persons as control group.The patients were divided into 3 groups according to the Ccr. CysC was determined by the particle enhanced turbidimetric immunoassay(PETIA), Ccr﹤80ml/min/1.73m2 was regarded as renal dysfunction.Their sensitivity, accuracy and specialization were compared. Results Serum CysC of patients increased significantly but Ccr decreased.Ccr negatively correlated with CysC,Scr,Urea,Ualb,U0.806,-0.491,-0.542, P﹤0.01). The sensitivity of CysC was better than those of others. Conclusion Cystatin C may be an ideal marker of GFR and Cystatin C assay be used as a normal method for the purpose of diagnosisng the early renal disease.