Clinical application of cystatin C in kidney disease

Objective To discuss the diagnostic value of using serum Cystatin C(CysC) as an early sensitive mark in kidney functional impairment.Methods The latex enhanced immunoturbidimetric method was adopted to test the concentration of serum CysC,and serum creatinine(Scr) was simultaneously detected.Results The value of serum CysC in control group,kidney function reserve descent group,kidney insufficiency group,kidney failure group and uremia group were(0.76±0.14) mg/L,(1.95±0.61) mg/L,(2.78±0.86) mg/L,(6.23±1.68) mg/L and(7.93±1.25) mg/L respectively.With the increase of kidney function impairment,serum CysC concentration was elevated.The difference of serum CysC among adjacent groups had statistical significance(P0.05).The value of CysC in normal kidney function group was statistically different from that in the normal control group,while the Scr values had no statistical difference(P0.05).Conclusion Serum cystatin C is a sensitive mark to reflect the kidney impairment,which could be used to judge the glomerular filtration function instead of the endogenous creatinine clearance(Ccr).Using cystatin C to evaluate the abnormal glomerular filtration rate(GFR) has a wide prospect.