Risk factors correlated with severity of coronary artery lesion and depression status in patients with coronary heart disease

Objective To analyze the glucose and lipid metabolic dysfunction and depression in coronary heart disease(CHD) patients with different degrees of coronary artery lesion.Methods A total of 117 patients underwent the first coronary arteriography in our hospital from April,2008 to June,2009 were divided into 3 groups,including non-CHD(control) group,coronary atherosclerosis(AS) group and percutaneous coronary intervention(PCI) group.The body mass index(BMI),waist(W),fasting plasma glucose(FPG),2-hour postprandial glucose(2hPG),glycosylated hemoglobin(HbA1c),glycosylated albumin(GA) and lipid profile(total cholesterol,triglyceride,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol) were evaluated in all patients.Depression was assessed with Self-rating Depression Scale(SDS).Results The severity of coronary artery lesion was positively correlated with age and GA,but negatively correlated with HDL cholesterol.After adjustment for age and sex,compared with that in the control group,depression scores were significantly higher in AS group and PCI group(27.53±1.39 vs 33.48±1.16,P=0.004 and 27.53±1.39 vs 32.17±1.86,P=0.024,respectively).Multivariate logistic regression analysis showed that age and HDL cholesterol were independently associated with CHD.Conclusion The CHD patients with coronary artery lesion have glucose and lipid metabolic dysfunction.Meanwhile their depression rates are higher than the control patients.The nurses should pay more attention to the patients' depressive symptoms to relieve their psychological problems.