The whole blood endotoxin and the histomorphological changes caused by obstructive jaundice in rats

OBJECTIVE To study the the content of plasma endotoxin and the histomorphological changes of liver and small intestinal membrane caused by obstructive jaundice in rats. METHODS After executing rats in obstructive jaundice groups for 1,2 weeks and pseudo operative group with bleeding,the content of serum bilirubin and endotoxin was monitored and the histomorphological transformation of the liver and the small intestine was observed in different period of obstructive jaundice by light microscope and electron microscope. RESULTS The content of serum bilirubin and endotoxin in the obstructive jaundice groups for 1,2 weeks was obviously increased,respectively,and there was significant difference compared with pseudo operative group.The damage of liver was becoming heavier while the obstruction was prolonged,but the damage of the small intestinal membrane was much slighter. CONCLUSION When happening obstructive jaundice,the occurring and the development of endotoxemia is closely correlated with the protective barrier function of small intestinal membrane in rats.