THE EXPERIMENTAL RESEARCH ON THE RELATIONSHIP BETWEEN STAT3 AND BLASTOCYST IMPLANTATION

Objective To investigate the expressions and the significance of signal transducer and activator of transcription 3(STAT3) in mouse endometrium during blastocyst implantation.Methods Uterus of nonpregnant (estrous stage),pregnant for 1～8 days in mice were obtained.Immunohistochemistry was used to observe and analyze the expressions and distribution of STAT3 in the uterine endometrium during early pregnancy.An image analysis was also performed.Results STAT3-specific staining was mainly distributed in the luminal epithelium,glandular epithelium and decidual cells.The expressions of STAT3 were strengthened gradually with pregnancy in the luminal and glandular endometrium,peak at 4th day,then declined,but increased in decidual cells.STAT3 was expressed weakly in the endometrium of nonpregnant mouse.Conclusion STAT3 participates in blastocyst implantation and the establishment of uterine receptivity.STAT3 may also indirectly participate in the process of trophoblast outgrowth,differentiation and decidualization of endometrium.