Analysis of maternal plasma D-dimer and coagulation changes during different periods of pregnancy

Objective To investigate the maternal plasma D-dimerand coagulation changes of different periods of pregnanc, and to analyze and monitor clinical significance of changes of D-dimer and coagulation. Methods 260 cases of pregnant women with regular routine examination of Obstetrics and Gynecology in our hospital from October 2012 to October 2013 were seleted for the study, according to the trimester of pregnancy, at an early stage, mid-pregnancy, late pregnancy, before labor plasma D-dimer and coagulation were detected and the results were analyzed using statistical software. Results D-dimer(D-Dimer) was progressively increased(P 0.05) in pregnant women throughout pregnancy process: prothrombin time(PT) in early pregnancy, second trimester, the latter process was progressively shortened pregnancy(P 0.05), late pregnancy to the perinatal period had no significant changes in PT(P 0.05); thrombin time(TT) changes throughout the course of pregnancy in pregnant women was not statistically significant(P 0.05); activated partial thromboplastin time(APTT) was gradually shortened trend among pregnant women during pregnancy in the early second trimester of pregnancy to significantly shorten the trend(P 0.01); changes between the late second trimester of pregnancy was not statistically significant(P 0.05), the latter stages of pregnancy to the perinatal period was significantly shorter(P 0.05); fibrinogen(FIB) to mid-pregnancy was significantly higher(P 0.01) in early pregnancy; second trimester of pregnancy to the late had no significant change(P 0.05). There was a sharp increase in the late stages of pregnancy to the perinatal period(P 0.01). Conclusion Dynamic monitoring the changes of plasma D-dimer and coagulation during pregnancy can help prevent birth complications during childbirth and postpartum abnormal bleeding, disseminated intravascular coagulation, and arterial and venous thrombosis diseases, which has important clinical significance.