Comparison of Therapeutic Efficacy of Nifedipine and Amlodipine for Primary Hypertension

OBJECTIVE:To compare clinical efficacy and adverse drug reaction of nifedipine and amlodipine for primary hypertension.METHODS:112 Primary hypertension patients admitted in our hospital during Feb.2010-Feb.2012 were randomized into study group and control group.Control group received therapy of nifedipine(30 mg,qd)while study group received amlodipine(5 mg,qd).Clinical efficacies and adverse drug reactions were compared between 2 kinds of drugs.RESULTS:There was no statistical significance in systolic pressure and diastolic pressure between 2 groups(P0.05).Total effective rate of lowering blood pressure was 92.6% in study group and 85.71% in control group,there was no statistical significance in 2 groups(P0.05).Renal function index of study group was improved significantly after treatment(P0.05),while there was no significant change in control group(P0.05).The incidence of ADR in study group(5.36%)was significantly lower than in control group(17.86%),there was statistical significance(P0.05).CONCLUSION:Nifedipine and amlodipine can lower blood pressure significantly,but the incidence of ADR induced by amlodipine is lower than nifedipine except for sound hypotensive effect and compliance.