Effect of Shuweitang on Expression of Interstitial Cells of Cajal and Motilin in Functional Dyspepsia Rats

Objective:To observe the effects and mechanism of Shuweitang on expression of interstitial cells of cajal(ICC) and motilin(MTL)in functional dyspepsia(FD) rats.Method:FD model was induced by moderate enraging the rats' tail.All rats were divided random1y into 6 groups: control group,model group,high and low dosages of Shuweitang groups,domperidone and Muxiangshunqi groups.Drugs were administrated for 14 days.ICC and MTL were determined by immunohistochemical method.And gastric emptying was observed with phenolsu1fonphthalein.Result:Compared with the control group,gastric emptying and the expression of ICC and MTL in the model groups were obviously decreased(P 0.05).Compared with model group,gastric emptying,MTL and ICC increased significantly in high-dose Shuweitang,Muxiangshunqi and domperidone groups(P 0.05).Low dose of Shuweitang showed no significant differences(P 0.05).Conclusion:High dose of Shuweitang may increase diet and water intake,promote ICC and MTL expression in FD rats,and accelerate gastric emptying.