Distribution and antimicrobial resistance of pathogenic bacteria causing urinary tract infection in children

OBJECTIVE To study the distribution and antimicrobial resistance of pathogenic bacteria causing urinary tract infection in children and provide reference for clinical use of antibiotics.METHODS The strains isolated from midstream urine specimen from Jan.2009 to Dec.2010 were included in this study.The positive results of urine culture were analyzed statistically.Referring to National Guide to Clinical Laboratory Procedures,the strains were cultured and identified.Susceptibility testing was performed by disc diffusion method.The drug susceptibility results were assessed according to CLSI 2009-2010 breakpoints.RESULTS Among the 223 isolates,the majority were Escherichia coli which accounted for 38.1%,followed by Enterococci,accounting for 18.8%.Except for 100.0% sensitivity rate of carbapenems to gram-negative bacilli and of glycopeptides to gram-positive cocci,the pathogenic bacteria causing urinary tract infection in children were resistant to the most commonly used antibiotics of varying degrees.CONCLUSION The clinical abuse of broad-spectrum antibiotics is closely related to the increasing drug resistance of pathogenic bacteria causing urinary tract infection in children.We should intervene by taking effective measures.