Pharmacokinetics and Bioavailability of Captopril in Healthy Volunteers

OBJECTIVES:To compare the bioavailability and pharmacokinetics of captopril between products of two factories.METHODS:An open randomized crossover study was carried out in 9 healthy volunteers who received a single oral dose of 30mg captopril,taking β bromophenacyl bromide as ramification.Drug concentrations in plasma were assayed by HPLC method.RESULTS:The concentration time course after medication conformed to a 2 compartment open model with a first order absorption.The pharmacokinetic parameters of Captopril of A and B medicine factories were:Tmax(0.94±0.13)h,(1.00±0.15)h,Cmax(92.03±27.36)ng/ml,(74.67±19.29)ng/ml,AUC(252.78±68.14)ng/(h·L),(251.19±50.13)ng/(h·L)respectively.CONCLUSIONS:The results showed that the bioavailability for the testing tablet was 99.37%,the two formulations were bioequivalent.