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2003•Chinese Journal of PharmaceuticsRequires access

Study on the relative bioavailability of captopril tablets in volunteers

Zhang Shu-y

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Abstract

Objective To study the relative bioavailability of captopril tablets in human being.Methods The randomized,crossed-over study was conducted in 18 healthy volunteers.After a single dose(containing 100 mg captopril),the plasma drug levels were determined by RP-HPLC.Results The main pharmacokinetic parameters of captopril in the test and reference formulation were as follows: tmax were( 0.83±0.23) and(0.81±0.28) h;cmax were(22.88±13.64) and(20.96±8.06) mg·L-1,t1/2were(1.95±0.11)and(1.89±0.11) h;AUC0→∝were(66.92±11.15) and(67.85±12.33) mg·h·L-1,respectively.Conclusion It can be showed that the two formulations are bioequivalent.

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What this paper is about

Objective To study the relative bioavailability of captopril tablets in human being.Methods The randomized,crossed-over study was conducted in 18 healthy volunteers.After a single dose(containing 100 mg captopril),the plasma drug levels were determined by RP-HPLC.Results The main pharmacokinetic parameters of captopril in the test and reference formulation were as follows: tmax were( 0.83±0.23) and(0.81±0.28) h;cmax were(22.88±13.64) and(20.96±8.06) mg·L-1,t1/2were(1.95±0.11)and(1.89±0.11) h;AUC0→∝were(66.92±11.15) and(67.85±12.33) mg·h·L-1,respectively.Conclusion It can be showed that the two formulations are bioequivalent.

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Available abstract

Objective To study the relative bioavailability of captopril tablets in human being.Methods The randomized,crossed-over study was conducted in 18 healthy volunteers.After a single dose(containing 100 mg captopril),the plasma drug levels were determined by RP-HPLC.Results The main pharmacokinetic parameters of captopril in the test and reference formulation were as follows: tmax were( 0.83±0.23) and(0.81±0.28) h;cmax were(22.88±13.64) and(20.96±8.06) mg·L-1,t1/2were(1.95±0.11)and(1.89±0.11) h;AUC0→∝were(66.92±11.15) and(67.85±12.33) mg·h·L-1,respectively.Conclusion It can be showed that the two formulations are bioequivalent.

Key concepts: Captopril, Bioavailability, Bioequivalence, Cmax, Pharmacokinetics, Pharmacology, Pharmaceutics, Chemistry

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