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Effects of Di-ao-xin-xue-kang on myocardial ischemia and hemodynamics in dogs

Shang Xiao, Zheng Zhou

Abstract

The effects of Di-ao-xin-xue-kang(DAXXK)on acute myocardial ischemia and hemodynamics caused by ligating coronary artery were studied in dogs.The results showed that DAXXK(10 mg/kg,iv) reduced obviously the range and degree of myocardial ischemia,slowed down the heart rate,decreased the blood pressure,cardiac output,left ventricle pressure,left ventricle work,myocardial oxygen consumption,coronary resistance.total peripheral resistance,and also increased the coronary arterial blood flow.The results suggest DAXXK can prevent heart from myocardial ischemia and change some indices of hemodynamics significantly.

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Key concepts: Hemodynamics, Medicine, Cardiology, Myocardial ischemia, Ventricle, Internal medicine, Heart rate, Ischemia