Clinical effect of Mifepristone combined Misoprostol together with complete curettage of uterine cavity in terminating pregnancy of 8-12 weeks

Objective To study the clinical effect of Mifepristone combined Misoprostol together with complete curettage of uterine cavity in terminating pregnancy of 8 to 12 weeks. Methods 240 patients receiving termination of pregnancy operation in the Department of Obstetrics and Gynecology out-patient of Ren County Hospital of Xingtai City from May 2012 to May 2013, who were intrauterine pregnancy and gestation with 8-12 weeks, were randomly divided into the observation group and the control group, 120 cases in each group. The observation group was given the treatment of Mifepristone combined Misoprostol together with complete curettage of uterine cavity, and the patients of control group were was given the treatment of abortion with 0.2% Lidocaine local infiltration preoperative anesthesia. Operation success rate, operation time, intraoperative bleeding volume, cervical dilatation, pain and postoperative side effects, such as nausea, vomiting, fever, abdominal pain, diarrhea, bleeding, numbness in the hand were observed. Results The difference between the observation group operation success rate(98.3%) and the control group patients induced abortion operation success rate(99.2%) was not significant(P 0.05), but the dilatation of cervix total efficiency in the observation group(98.3%) was significantly higher than that in the control group(77.5%), the difference was statistically significant(χ2=12.31, P 0.05). The operation time, the amount of bleeding and severe pain of observation group were(4.80±0.86) min,(10.70±2.57) mL and(1.90±0.51), which were significantly less than that of the control group[(7.30±1.23) min,(16.60±4.32) mL,(2.38±0.67)], there were significant differences between the two groups(P 0.05).The patients of two groups had adverse reactions with different degree, but the two groups had no significant difference(P 0.05). Conclusion Mifepristone combined Misoprostol together with complete curettage of uterine cavity in terminating pregnancy of 8-12 weeks can promote cervical relaxation, make cervical softening, reduce trauma, and can relieve the distress of patients, reduce the amount of bleeding. It is a safe, effective, practical method of abortion, worthy of promotion.