Short-term effect of mosapride in treating reflux esophagitis

AIM: To observe the effects of mosapride in treating reflux esophagitis. METHODS: Eighty four patients with reflux esophagitis were divided into two groups. Fifty three patients (M 36,F 17; age 43 a± s 8 a)were treated with mosapride 5 mg po ,qid.Thirty one patients (M 18,F 13; age 41 a±6 a) were treated with omeprazole 20 mg po, bid. After 8 wk, the score of the symptom and the change of esophagitic degree before and after treatment were observed and the statistics were taken by t test. RESULTS: The score of mosapride groups symptom after 8 wk treatment was 14.1± 0.9 and the score of esophagitis degree was 1.4± 0.7 , which were more significant than those (66±5, 2.8 ±0.6) before the treatment( P 0.01). Compared with omeprazole group, the rate had no significant differences. CONCLUSION: Mosapride obviously relieved the symptom of gastric esophageal reflux, and its therapeutic effect was better in curing reflux esophagitis. It either decreased the degree of reflux esophagitis or healed it.