Association between rs2880416 polymorphism in peptide YY gene and obesity in rural adults of Henan Province

Aim: To explore the relationship between polymorphisms of the peptide YY( PYY) gene rs2880416 site and obesity susceptibility in Henan rural adults. Methods: A total of 410 cases of obesity and 410 cases without obesity were selected in a certain rural area of Henan to test the physical indicators,blood biochemical indicators and the rs2880416 polymorphism. Results: Two alleles including C and G,and three genotypes including CC,CG and GG,were detected,and there were significant differences in allele frequency and genotype frequency distribution between the two groups( χ2= 53. 110 and 56. 842,P 0. 001); the C allele frequency in obesity group was higher( P 0. 001). Based on that the physical exercise was adjusted,in the recessive model,the obesity risk of CC genotype carriers was 2. 327 times the GG /CG carriers( OR = 2. 327,95% CI = 1. 338- 4. 047); in the dominant model,that of the CC /CG genotype carriers was 3. 013 times the GG carriers( OR = 3. 013,95% CI = 2. 257- 4. 023); in the additive model,that of the C allele carriers increased 1. 337-fold in turn( OR = 2. 337,95% CI = 1. 845- 2. 961). The differences in BMI,waist circumference,or waist-to-height were not statistically significant among the 3 genotype carriers in obesity group( F = 1. 931,0. 235,0. 115,P 0. 05). Conclusion: The C allele of rs2880416 site in peptide YY gene is susceptible for obesity.