Research on Relationship Between Apolipoprotein C3 Gene C3175G Polymorphism and Overweight-Obesity in Male

Aim To study the relationship between apolipoprotein C3 gene C3175G polymorphism and overweight-obesity in male,as well as the risk factors of overweight-obesity. Methods A total 154 normal weight subjects(control group) and 184 overweight-obese subjects(case group) were selected from one hospital in Chongqing during the period of May,2008 to Sep,2008.PCR-RFLP was applied to analyze the polymorphism,and logistic regression was used for the analysis of the risk factors of overweight-obesity. Results Genotype frequeney distribution of CC,CG and GG were 51.78%,39.94%,8.28% respectively,C and G allele frequencies were 71.75% and 28.25%.There was no significant difference of CC genotype,CG genotype,GG genotype and C allele,G allele between case group(47.28%,44.57%,8.15%,69.57%,30.43%) and control group(57.14%,34.42%,8.44%,74.35%,25.65%).In each group,there was no significant difference for the level of age,serum total cholesterol(TC),high density lipoprotein(HDL) and low density lipoprotein(LDL) between the 2 C3175G genotypes,except waist-hip ratio(WHR),triglyceride(TG) between the 2 C3175G genotypes in control group.The logistic regression analysis showed that TG may be the risk factor of overweight-obesity. Conclusion The polymorphism of Apolipoprotein C3 gene C6175G may not be associated with overweight-obesity,but the persons with CC gene type are more likely to suffer from central obesity.