Correlation Study on Obesity and A Single Nucleotide Polymorphism in Adolescents

Objective To explore the relationships between obesity and the single nucleotide polymorphism rs7566605 in Chinese adolescents,and to provide reference for the research on the incidence of rs7566605 in Chinese people.Methods Altogether 919 middle-school students were selected from Dongcheng District,Beijing.Physical examination and the polymorphism analysis were performed for all subjects.Results The frequency of rs7566605 C-allele was 35.9%,similar to that of European and Americans.The differences of genotype and frequencies were not statistically significant among the normal-weight,overweight and obesity groups(P0.05).However,the frequency of CC genotype of the extremely obese students was significantly higher than that of the normal-weight group,which was 18.5% and 10.3% respectively.The carrier of CC genotype was more likely to become extremely obese than the GG/GC carrier(OR=1.101,P0.05).The average BMI of CC carriers was 0.88 kg/m~2 higher than that of GG/GC people(P0.05).Conclusion The single nucleotide polymorphism rs7566605 is associated with extremely obesity in Chinese adolescents.The carrier of CC genotype has higher risk to become extremely obese.