A Study on Relationship between PAPP-A, CRP and Acute Coronary Syndrome

Objective To observe the relationship between pregnancy-associated plasma protein-A (PAPP-A), C-reactive protein (CRP) and acute coronary syndrome (ACS). Methods Sixty-eight patients with coronary artery disease, who were confirmed by angiography, were enrolled in this study. Among them, there were 43 cases with ACS and 25 cases with stable angina. At the same time, randomly selective 20 healthy subjects served as control group. Plasma PAPP-A and CRP levels were measured by using untrasensitive immunosorbent assay (ELISA). Results The plasma levels of PAPP-A and CRP were significantly higher in ACS patients than those in control group (PAPP-A: 17.9±8.7mIu/L VS 7.1±4.2mIu/L, P0.01; CRP: 4.31±0.38mg/L VS 2.01±0.14mg/L, P0.01). The plasma levels of PAPP-A and CRP were also significantly higher in ACS patients than those in stable angina patients (PAPP-A: 17.9±8.7mIu/L VS 8.5±5.6mIu/L, P0.01; CRP: 4.31±0.38mg/L VS 2.13±0.28mg/L, P0.05). Logistic regression analysis showed that the odds ratio (OR) of PAPP-A/CRP were1, which indicated both were the risk factors of ACS. Conclusion The plasma levels of PAPP-A and CRP increased in ACS patients, and both PAPP-A and CRP were independent risk factors of ACS.