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CHANGES OF ACTIVITY OF LIVER GLYCOGENSYNTHASE IN EXPERIMENTAL DIABETIC RATS

Yanrong Wang

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Abstract

Objective: To study the activity of liver glycogen synthase in analogous model of NIDDM rats. Methods: 40 male Wistar rats were divided into two groups at random. Each group consisted of 20 rats. The rats of one group were injected with low dose of streptozotocin(STZ)(30 mg/kg)via tail vena. The rats of the other group used as control were not injected with STZ. The rats among the group were injected with STZ whose glucose tolerance was impaired and the level of insulin equal to or higher than that of the control. After 18 weeks they were taken as the analogous rat model of NIDDM. The activity of liver glycogen synthase (GS)was assayed at the end of the experiment. Results: Type I  enzyme: (0.18±0.06) μmol/(min·g )versus (0.24±0.09) μmol/(min·g) (P0.05), and totalenzyme: (1.5±0 .4) μmol/(min·g)versus (1.8±0.4) μmol/(min·g) (P0.05). Conclusion: The GS activity of diabetic rats was significantly lower than that of the control.

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Objective: To study the activity of liver glycogen synthase in analogous model of NIDDM rats. Methods: 40 male Wistar rats were divided into two groups at random. Each group consisted of 20 rats. The rats of one group were injected with low dose of streptozotocin(STZ)(30 mg/kg)via tail vena. The rats of the other group used as control were not injected with STZ. The rats among the group were injected with STZ whose glucose tolerance was impaired and the level of insulin equal to or higher than that of the control. After 18 weeks they were taken as the analogous rat model of NIDDM. The activity of liver glycogen synthase (GS)was assayed at the end of the experiment. Results: Type I  enzyme: (0.18±0.06) μmol/(min·g )versus (0.24±0.09) μmol/(min·g) (P0.05), and totalenzyme: (1.5±0 .4) μmol/(min·g)versus (1.8±0.4) μmol/(min·g) (P0.05). Conclusion: The GS activity of diabetic rats was significantly lower than that of the control.

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Available abstract

Objective: To study the activity of liver glycogen synthase in analogous model of NIDDM rats. Methods: 40 male Wistar rats were divided into two groups at random. Each group consisted of 20 rats. The rats of one group were injected with low dose of streptozotocin(STZ)(30 mg/kg)via tail vena. The rats of the other group used as control were not injected with STZ. The rats among the group were injected with STZ whose glucose tolerance was impaired and the level of insulin equal to or higher than that of the control. After 18 weeks they were taken as the analogous rat model of NIDDM. The activity of liver glycogen synthase (GS)was assayed at the end of the experiment. Results: Type I  enzyme: (0.18±0.06) μmol/(min·g )versus (0.24±0.09) μmol/(min·g) (P0.05), and totalenzyme: (1.5±0 .4) μmol/(min·g)versus (1.8±0.4) μmol/(min·g) (P0.05). Conclusion: The GS activity of diabetic rats was significantly lower than that of the control.

Key concepts: Internal medicine, Streptozotocin, Endocrinology, Glycogen, Glycogen synthase, Enzyme, Chemistry, Diabetes mellitus

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