Expressions of heat shock protein 70,P27 and Bcl-2 protein in mucoepidermoid carcinoma of salivary glands and clinical significances

Objective To study the expressions of Hsp70,P27,Bcl-2 in mucoepidermoid carcinoma of salivary glands and clinical significances.Methods Forty cases of mucoepidermoid carcinoma of salivary glands were chosen and the expressions of Hsp70,P27,Bcl-2 were detected by the method of immunohistochemistry,10 cases of polymorphic adenoma were chosen as control group.Results Both Hsp70 and P27 were stained with aliomycin in nucleus and cytoplasm,the positive rates of them were 75% and 27.5%,respectively,there were significant differences compared with control group(P0.01).Bcl-2 was stained with aliomycin or brown,the positive expression rate was 62.5% and there was no significant difference compared with control group(P0.05).The expressions of Hsp70 and P27 had significant differences in different clinical stages,different histological grades and lymph node metastasis(P0.05 or P0.01),the expression of Bcl-2 had significant difference in different clinical stages(P0.05),while no significant difference in different histological grades and lymph node metastasis of mucoepidermoid carcinoma of salivary glands(P0.05).Conclusion The expressions of Hsp70 and P27 can be used to estimate prognosis of patients with mucoepidermoid carcinoma.Hsp70 and Bcl-2 can inhibit apoptosis by different ways.