Expressions and clinical significances of P53,Bcl-2 protein and Cyclin D1 in mucoepidermoid carcinoma of salivary glands

Objective To study the expressions and clinical significances of P53,Bcl-2,Cyclin D1 in mucoepidermoid carcinoma of salivary glands.MethodsThe immunohistochemical method was used to detect the expressions of P53,Bcl-2,Cyclin D1 in 26 cases of mucoepidermoid carcinoma(MEC)and 15 cases of polymorphic adenoma(PAS).ResultsP53 and Cyclin D1 expressions were not observed in PAS and the positive rates of them in MES group were 62%and 73%respectively.There were significant differences compared with control group(P0.01).Bcl-2 of the positive expressions rate was 47%and ther was no significant differences compared with that of the control group(P0.05).The expressions of P53 and Cyclin D1 had significant differences in different clinical stages,different histological grades and lymph node metastasis(P0.01,P0.05);The expression of Bcl-2 had significant differences in different clinical stages(P0.05),while no significant differences in different histological grades and lymph node metastasis of mucoepidermoid carcinoma of salivary glands(P0.05).ConclusionCombined analysis of the expressions of P53,Bcl-2 and Cyclin D1 might be usefulo make the diagnosis and prognosis of mucoepidermoid carcinoma.