Expression of RRIG1 gene mRNA in breast carcinoma and its clinicopathologic significance

Purpose To investigate the expression of RRIG1 mRNA and their relationships with clinicopathologic characters in breast carcinoma.Methods Real time quantitative reverse transcription polymerase chain reaction(RQ RT-PCR) technique was applied for detecting RRIG1 mRNA expression in 76 cases of breast carcinoma,5 cases of ductal carcinoma in situ and 20 cases of breast benign lesions.Results The level of mRNA expression of RRIG1 gene was significantly higher in breast benign 1esions(10.2±6.5) than in ductal carcinoma in situ(3.5±2.1) and invasive breast carcinoma(6.7±4.1)(P=0.004 and 0.036,respectively).RRIG1 mRNA expression is significantly lower in lymph node positive(5.2±3.1) than in non lymph node negative cases(7.48±4.5)(P=0.023).Conclusions RRIG1 may play a important role in disease occurrence and progression of breast carcinoma,RRIG1 may be a new biomarker for early diagnosis and prognosis in breast cancer.