Expression of mRNAs missing in metastasis in primary breast carcinoma and its clinical significance

Objective: To detect the expression of missing in metastasis(MIM) in human primary breast carcinoma and to evaluate its correlation with clinicopathological features.Methods: The expression of MIM mRNA was detected by SYBR Green quantitative real-time PCR in 60 samples of primary breast carcinoma and adjacent normal tissues,and its expression level was interpreted in terms of various clinical characteristics.Results: The expression of MIM mRNA in breast carcinoma was higher than that of adjacent tissues(P0.05) and it was associated with lymph node metastasis(P0.01),tumor size,and TNM stages(P0.05),but not age,histological grade,pathological type,ER,PR,CerbB-2 and Ki-67(P0.05).Conclusion: Overexpression of MIM mRNA may be a useful marker to predict metastasis of breast carcinoma.It may served as a biomarker for the prediction of moderate or advanced breast carcinoma,and may also prove to be a potential therapeutic target in breast carcinoma.