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2002•Journal of Clinaical UrologyRequires access

Expression and significance of TGFβ 1 and αSMA in human renal pelvis of hydronephrosis

Tao Wang

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Abstract

Purpose:To detect the expression of TGFβ 1 and αSMA in renal pelvis of hydronephrosis and to investigate the protective role of TGFβ 1 in the pathophysiologic course of hydronephrosis.Methods:The expression of TGFβ 1 and αSMA protein was determined in 30 renal pelvis specimens with hydronephrosis and 5 normal control specimens by immunohistochemistry. Results:The expression of TGFβ 1 and αSMA are obviously increased in muscle layer of hydronephrotic renal pelvis compared to the normal renal pelvis specimens, P 0.01 , and TGFβ 1 statistically correlates positively to αSMA, r= 0.71 ,P 0.05 . Conclusions:TGFβ 1 may be one of the protective factors in the pathophysiologic course of hydronephrosis by inducing muscle hypertrophy of renal pelvis.

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Purpose:To detect the expression of TGFβ 1 and αSMA in renal pelvis of hydronephrosis and to investigate the protective role of TGFβ 1 in the pathophysiologic course of hydronephrosis.Methods:The expression of TGFβ 1 and αSMA protein was determined in 30 renal pelvis specimens with hydronephrosis and 5 normal control specimens by immunohistochemistry. Results:The expression of TGFβ 1 and αSMA are obviously increased in muscle layer of hydronephrotic renal pelvis compared to the normal renal pelvis specimens, P 0.01 , and TGFβ 1 statistically correlates positively to αSMA, r= 0.71 ,P 0.05 . Conclusions:TGFβ 1 may be one of the protective factors in the pathophysiologic course of hydronephrosis by inducing muscle hypertrophy of renal pelvis.

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Available abstract

Purpose:To detect the expression of TGFβ 1 and αSMA in renal pelvis of hydronephrosis and to investigate the protective role of TGFβ 1 in the pathophysiologic course of hydronephrosis.Methods:The expression of TGFβ 1 and αSMA protein was determined in 30 renal pelvis specimens with hydronephrosis and 5 normal control specimens by immunohistochemistry. Results:The expression of TGFβ 1 and αSMA are obviously increased in muscle layer of hydronephrotic renal pelvis compared to the normal renal pelvis specimens, P 0.01 , and TGFβ 1 statistically correlates positively to αSMA, r= 0.71 ,P 0.05 . Conclusions:TGFβ 1 may be one of the protective factors in the pathophysiologic course of hydronephrosis by inducing muscle hypertrophy of renal pelvis.

Key concepts: Renal pelvis, Hydronephrosis, SMA*, Medicine, Pathophysiology, Immunohistochemistry, Transforming growth factor, Kidney

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Expression and significance of TGFβ 1 and αSMA in human renal pelvis of hydronephrosis — Research Paper | ScholarLens