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The expression of EGF and TGF-β1 in congenital hydronephrosis

杨屹, 吉士俊, Wei Wang, 赵国贵, 王常林

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Abstract

Objective To evaluate the expression of EGF and TGF-β1 in congenital hydronephro sis. Methods The expression of EGF and TGF-β1 protein was determined in 15 renal specimens with hydronephrosis and 6 normal control specimens by immunohistochemisty. Results The expression of EGF protein was obviously reduced; there was mild positive expression of EGF protein in a few tubular cells in 2cases. The expression of TGF-β1 significantly increased and it was mainly localized in proximal tubular cells.Conclusions The abnormal expression of EGF and TGF-β1 in congenital hydronephrosis might related to the degree of hydronephrosis, renal atrophy and interstitial fibrosis.

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Objective To evaluate the expression of EGF and TGF-β1 in congenital hydronephro sis. Methods The expression of EGF and TGF-β1 protein was determined in 15 renal specimens with hydronephrosis and 6 normal control specimens by immunohistochemisty. Results The expression of EGF protein was obviously reduced; there was mild positive expression of EGF protein in a few tubular cells in 2cases. The expression of TGF-β1 significantly increased and it was mainly localized in proximal tubular cells.Conclusions The abnormal expression of EGF and TGF-β1 in congenital hydronephrosis might related to the degree of hydronephrosis, renal atrophy and interstitial fibrosis.

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Available abstract

Objective To evaluate the expression of EGF and TGF-β1 in congenital hydronephro sis. Methods The expression of EGF and TGF-β1 protein was determined in 15 renal specimens with hydronephrosis and 6 normal control specimens by immunohistochemisty. Results The expression of EGF protein was obviously reduced; there was mild positive expression of EGF protein in a few tubular cells in 2cases. The expression of TGF-β1 significantly increased and it was mainly localized in proximal tubular cells.Conclusions The abnormal expression of EGF and TGF-β1 in congenital hydronephrosis might related to the degree of hydronephrosis, renal atrophy and interstitial fibrosis.

Key concepts: Hydronephrosis, Transforming growth factor, Protein expression, Kidney, Atrophy, Medicine, Internal medicine, Endocrinology

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