2007•Zhongguo yaofangRequires access

Determination of Harpagosicle in Junduqing Granule by RP-HPLC Method

Zhong Zhao-jian, Xiao Ruo-mei

Abstract

OBJECTIVE:To develop a RP-HPLC method for the determination of Harpagosicle in Junduqing granule.METHODS:The chromatographic column was Diamonsil-C18(250mm× 4.6mm,5μ m) at room temperature.The mobile phase was acetonitrile-1% HAc(gradient elution).The flow rate was 1.0mL· min-1 and the detection wavelength was 278 nm.RESULTS:The linear range of Harpagosicle was 2.55～ 20.4μg· mL-1,with average recovery at 96.6%,RSD=0.67%(n=6).CONCLUSION:The method was proved to be sensitive and accurate,and it can be used as quality control of Junduqing granule.

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Key concepts: Chromatography, Granule (geology), Chemistry, Gradient elution, High-performance liquid chromatography, Linear range, Linear relationship, Analytical Chemistry (journal)