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2000•The Practical Journal of CancerRequires access

Expression and Significance of p53 Protein and PCNA in Primary Lung Cancer

Zhiying Huang

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Abstract

Objective To investigate the relationship between p53 protein and proliferating cell nuclear antigen(PCNA) and the clinical significance in primary lung cancer.Methods S-P immunohistochemistry method was used in 101 cases of primary lung cancer tissue.Results Abnomalities in p53 expression were found,the positive ratios was 59.4%(60/101).p53 overexpression were associated with tumor grading and survival time( P 0.05).A significantly higher PCNA expression score was found in the p53-positive samples( P 0.05).Conclusion This finding suggests that overexpression of p53 could be used as an independent prognostic factor for the patients with lung cancer.

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What this paper is about

Objective To investigate the relationship between p53 protein and proliferating cell nuclear antigen(PCNA) and the clinical significance in primary lung cancer.Methods S-P immunohistochemistry method was used in 101 cases of primary lung cancer tissue.Results Abnomalities in p53 expression were found,the positive ratios was 59.4%(60/101).p53 overexpression were associated with tumor grading and survival time( P 0.05).A significantly higher PCNA expression score was found in the p53-positive samples( P 0.05).Conclusion This finding suggests that overexpression of p53 could be used as an independent prognostic factor for the patients with lung cancer.

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Available abstract

Objective To investigate the relationship between p53 protein and proliferating cell nuclear antigen(PCNA) and the clinical significance in primary lung cancer.Methods S-P immunohistochemistry method was used in 101 cases of primary lung cancer tissue.Results Abnomalities in p53 expression were found,the positive ratios was 59.4%(60/101).p53 overexpression were associated with tumor grading and survival time( P 0.05).A significantly higher PCNA expression score was found in the p53-positive samples( P 0.05).Conclusion This finding suggests that overexpression of p53 could be used as an independent prognostic factor for the patients with lung cancer.

Key concepts: Proliferating cell nuclear antigen, Immunohistochemistry, Grading (engineering), Lung cancer, Clinical significance, P53 protein, Cancer research, P53 expression

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