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2008•Zhongguo redai yixueRequires access

Effect of medroxyprogesterone and cisplatin-intensified mifepristone on drug-resistant ovary cells

Yuxia Liu

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Abstract

Objective To discuss the impact of mfeprostone(MPA) and medroxyprogesterone(RU486) acetate on drug resistance of human ovary cancer drug-ressistant cell line SKOV-3/DDP.Methods Thiazolyl blue was used and the impact of concentrations of MPA、RU486、MPA +RU486 on the growth of SKOV-3/DDP cell and the resistance of SKOV-3/DDP to DDP was observed.Results RU486 of certain concentration or MPA at relatively high concentration could inhibit the growth of SKOV-3/DDP cells and revsere the resistance to DDP,The resistance rate would increase along with the increased concentration of MPA at the same concentration.Conclusion MPA and RU486 is capable of reversing the drug resistance arised due to DDP,while combined use of MPA an RU486 can enhance the activity of DDP.Therefore MPA and RU486 might be used as an adjuvant in chemotherapy.

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What this paper is about

Objective To discuss the impact of mfeprostone(MPA) and medroxyprogesterone(RU486) acetate on drug resistance of human ovary cancer drug-ressistant cell line SKOV-3/DDP.Methods Thiazolyl blue was used and the impact of concentrations of MPA、RU486、MPA +RU486 on the growth of SKOV-3/DDP cell and the resistance of SKOV-3/DDP to DDP was observed.Results RU486 of certain concentration or MPA at relatively high concentration could inhibit the growth of SKOV-3/DDP cells and revsere the resistance to DDP,The resistance rate would increase along with the increased concentration of MPA at the same concentration.Conclusion MPA and RU486 is capable of reversing the drug resistance arised due to DDP,while combined use of MPA an RU486 can enhance the activity of DDP.Therefore MPA and RU486 might be used as an adjuvant in chemotherapy.

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Available abstract

Objective To discuss the impact of mfeprostone(MPA) and medroxyprogesterone(RU486) acetate on drug resistance of human ovary cancer drug-ressistant cell line SKOV-3/DDP.Methods Thiazolyl blue was used and the impact of concentrations of MPA、RU486、MPA +RU486 on the growth of SKOV-3/DDP cell and the resistance of SKOV-3/DDP to DDP was observed.Results RU486 of certain concentration or MPA at relatively high concentration could inhibit the growth of SKOV-3/DDP cells and revsere the resistance to DDP,The resistance rate would increase along with the increased concentration of MPA at the same concentration.Conclusion MPA and RU486 is capable of reversing the drug resistance arised due to DDP,while combined use of MPA an RU486 can enhance the activity of DDP.Therefore MPA and RU486 might be used as an adjuvant in chemotherapy.

Key concepts: Mifepristone, Medroxyprogesterone acetate, Medroxyprogesterone, Cisplatin, Pharmacology, Drug resistance, Ovary, Chemistry

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Effect of medroxyprogesterone and cisplatin-intensified mifepristone on drug-resistant ovary cells — Research Paper | ScholarLens