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2008•International Journal of Pathology and Clinical MedicineRequires access

Role of minichromosome maintenance proteins in cell cycle

Shengsong Tang

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Abstract

The minichromosome maintenance proteins(MCMs)are extensive existenced and conserved throughout archae to eukaryotic cells.MCM2～7 proteins are related to each other and form hexamer,functioning in the replication as DNA helicases at the initiation step and elongation step,to ensure the DNA precisely duplicated and segregated into two copies.MCM8 has helicases activity with normal function replication fork and the function of MCM9 is unknown.MCM1 and MCM10 are not related to MCM family but also function in DNA synthsis.

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What this paper is about

The minichromosome maintenance proteins(MCMs)are extensive existenced and conserved throughout archae to eukaryotic cells.MCM2～7 proteins are related to each other and form hexamer,functioning in the replication as DNA helicases at the initiation step and elongation step,to ensure the DNA precisely duplicated and segregated into two copies.MCM8 has helicases activity with normal function replication fork and the function of MCM9 is unknown.MCM1 and MCM10 are not related to MCM family but also function in DNA synthsis.

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Available abstract

The minichromosome maintenance proteins(MCMs)are extensive existenced and conserved throughout archae to eukaryotic cells.MCM2～7 proteins are related to each other and form hexamer,functioning in the replication as DNA helicases at the initiation step and elongation step,to ensure the DNA precisely duplicated and segregated into two copies.MCM8 has helicases activity with normal function replication fork and the function of MCM9 is unknown.MCM1 and MCM10 are not related to MCM family but also function in DNA synthsis.

Key concepts: Minichromosome maintenance, Helicase, Control of chromosome duplication, Origin recognition complex, Eukaryotic DNA replication, Pre-replication complex, DNA replication, Biology

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