Correlation between glycosylated hemoglobin,urine trace albumin and other biochemical indexes of type 2 diabetic nephropathic patients

Objective To investigate the relationship among glycosylated hemoglobin( GHb A1C),the disturbance of lipids metabolism and urinous albumin( m Alb) excretion rate in type 2 diabetic nephropathy( DN). Methods A hundred and twenty patients,in accordance with the urine trace albumin excretion rate,were assigned into normal albuminuria( NAU) group,microalbuminuria( MAU) group and clinical proteinuria( CAU) group,and in accordance with the glycated hemoglobin level were assigned into group A,B,and C,meanwhile,30 healthy people were chosen as the control group( NC). Various biochemical indexes including FBG,Hb A1 C,TCH,TG,BUN,Cr,HDL-C,LDL-C,m Alb were detected. Results Compared with NC group,the detection rates of FBG,TG,TC,LDL-C,Hb A1 C was higher in T2 DM group( P 0. 01),while HDL-C was lower( P 0. 05). FBG,TG,TC,LDL-C,Hb A1 C indexes in CAU,MAU group were significantly higher than those in NUA group( P 0. 05). FBG,TG,LDL-C,Hb A1 C in CAU group were significantly higher than those in MAU group( P 0. 01). HDL in CAU group was lower than that in MAU group and NUA group( P 0. 05). FPG,Hb A1 C,TCH,TG and UAE of patients with type 2 diabetic nephropathy were significantly different from those in NC group( P 0. 05),while BUN,Cr,compared with NC group,had no statistically significant difference( P 0. 05). FPG,Hb A1 C of T2 DM patients were statistically different among different groups( P 0. 05),while TCH,TG,BUN,Cr had no statistical significance( P 0. 05). Conclusions Increased urine trace albumin levels of type 2 diabetic nephropathic patients are associated with increased glycosylated hemoglobin. Urine trace albumin is a sensitive index of early diabetic kidney damage. Joint detection of Hb AlC,m Alb and lipid levels will have important significance in diabetic nephropathy's early prevention,diagnosis and treatment.