2001•中华医学杂志：英文版Requires access
Expression of β-catenin in renal cell carcinoma
Zang Tong
Open publisher page 2 citations
Abstract
Objective To investigate the expression of β catenin and its mRNA in renal cell carcinoma Methods Twenty six cases with renal cell carcinoma (RCC) were studied by immunohistochemistry, Western blot and RT PCR Results We found the expression of β catenis is higher in cancer tissues than in normal kidney tissues and the level of β catenin is associated with the tumor stage Its expression in tumor of pT3 and pT4 is obviously higher than pT1 and pT2 ( P 0 01) That is to say, there was an overexpression of β catenin protein in RCC and its level was related to the tumor stage, but the expression of β catenin mRNA had no difference between tumor tissue and normal tissue Conclusion β catenin may be related to the occurrence and progress of RCC