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Expression of beta-catenin in renal cell carcinoma.

Tong Zang, L Zhuang, Z Zhang, Xin D, Yang Guo

Open publisher page 10 citations

Abstract

OBJECTIVE: To investigate the expression of beta-catenin and its mRNA in renal cell carcinoma. METHODS: Twenty-six cases with renal cell carcinoma (RCC) were studied by immunohistochemistry, Western blot and RT-PCR. RESULTS: We found the expression of beta-catenis is higher in cancer tissues than in normal kidney tissues and the level of beta-catenin is associated with the tumor stage. Its expression in tumor of pT3 and pT4 is obviously higher than pT1 and pT2 (P < 0.01). That is to say, there was an overexpression of beta-catenin protein in RCC and its level was related to the tumor stage, but the expression of beta-catenin mRNA had no difference between tumor tissue and normal tissue. CONCLUSION: beta-catenin may be related to the occurrence and progress of RCC.

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What this paper is about

OBJECTIVE: To investigate the expression of beta-catenin and its mRNA in renal cell carcinoma. METHODS: Twenty-six cases with renal cell carcinoma (RCC) were studied by immunohistochemistry, Western blot and RT-PCR. RESULTS: We found the expression of beta-catenis is higher in cancer tissues than in normal kidney tissues and the level of beta-catenin is associated with the tumor stage. Its expression in tumor of pT3 and pT4 is obviously higher than pT1 and pT2 (P < 0.01). That is to say, there was an overexpression of beta-catenin protein in RCC and its level was related to the tumor stage, but the expression of beta-catenin mRNA had no difference between tumor tissue and normal tissue. CONCLUSION: beta-catenin may be related to the occurrence and progress of RCC.

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Available abstract

OBJECTIVE: To investigate the expression of beta-catenin and its mRNA in renal cell carcinoma. METHODS: Twenty-six cases with renal cell carcinoma (RCC) were studied by immunohistochemistry, Western blot and RT-PCR. RESULTS: We found the expression of beta-catenis is higher in cancer tissues than in normal kidney tissues and the level of beta-catenin is associated with the tumor stage. Its expression in tumor of pT3 and pT4 is obviously higher than pT1 and pT2 (P < 0.01). That is to say, there was an overexpression of beta-catenin protein in RCC and its level was related to the tumor stage, but the expression of beta-catenin mRNA had no difference between tumor tissue and normal tissue. CONCLUSION: beta-catenin may be related to the occurrence and progress of RCC.

Key concepts: Renal cell carcinoma, Immunohistochemistry, Beta-catenin, Catenin, BETA (programming language), Western blot, Carcinoma, Kidney

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