37 Samples of Patients with Early Serofast Syphilis Treated by the Large Dose Aqueous Penicillin

Objective To evaluate the efficacy and safety of large dose aqueous penicillin in the treatment of early serofast syphilis.Methods 37 patients with serofast syphilis were selected and iv drop with the large dose of aqueous penicillin 2400 pan U·d-1(400 panU per q4 h) for 14 consecutive days,then im with benzathine penicillin 240 panU,weekly for 3 times.Results In each stage of follow-up,the RPR test titer descended more than 2 titers was 48.6% for 3 months of treatment,78.4% for 6 months and 94.6% for 9 months,,the negative turning rate was 83.8% at 12 months.No side effects were shown during the whole treatment.Conclusion Large dose of aqueous penicillin is an effective and safety treatment for patients with early serofast syphilis.