The effect of cognitive intervention training on cognitive ability and auditory event related potential P300in patients with mild cognitive impairment

Objective:To discuss the affects of cognitive intervention training on cognitive ability and auditory event relat- ed potential P300 in patients with mild cognitive impairment(MCI). Method:Patients with MCI were randomly assigned either to cognitive intervention groups, receiving a 6-month cognitive intervention, or control group, receiving no intervention. Mini mental state examination(MMSE) and auditory event related potentials(ERPs) P300 test were administered at baseline and after six- month interven- tion to evaluate the intervention effect. Result:After six months, the P300 latency periods of intervention group(350.90±15.85) were shorter than be- fore(P0.05), and significantly shortened compared with control group(370.04±21.25,P0.01); The amplitude(12.01 ± 1.95) increased comparing with control group(P0.05);the scores of MMSE(26.19 ± 1.21)were higher than before(P0.05)and significantly higher compared with control group(24.52±1.34)(P0.01). The changes of P300 latency, amplitude and MMSE scores were not significant in control group(P0.05). Conclusion:Cognitive training can effectively prolong the decline of cognitive function improve the cognitive function significantly in MCI patients. Auditory ERPs P300 test can be used as a quantitative evaluation tool of cognitive function before and after the intervention for MCI patients.