Clinical Study on the Effect of TCM Syndrome Differentiation and Treatment on Peripheral Blood T Cell of IgAN

Objective: To observe the effect of TCM Treatment on IgA nephropathy of regulatory T cells in peripheral blood. Methods: 45 patients were randomly divided into spleen and kidney deficiency group,Qi and Yin deficiency group,liver and kidney Yin deficiency group and healthy control group,15 cases in each group. Healthy control group did not use any medication; Qi and Yin deficiency group was given replenishing Qi and nourishing Yin,clearing heat and removing dampness,with Qingxin Lianzi Yin;tspleen and kidney deficiency group was given tonifying kidney and spleen,clearing heat and removing dampness,with Shenqi Dihuang Tang; Yin deficiency of liver and kidney was given expelling heat and dampness,nourishing liver and kidney,with Liuwei Dihuang Tang,a total of 3 months. Results: 1compared with before treatment,urinary protein in the Qi and Yin deficiency group and liver and kidney Yin deficiency group significantly decreased( P 0. 05); Urinary protein in the spleen and kidney deficiency group also decreased compared with before treatment,but there was no statistical significance( P 0. 05). After TCM treatment for3 months,IgA nephropathy urine RBC count in groups were lower than those before treatment,and the difference was statistically significant( P 0. 01). 2After treatment for 3 months,IgAN each group peripheral blood CD4+,CD25+and forkhead box protein( Foxp3) was significantly lower than before treatment,and the difference was statistically significant( P 0. 05). Conclusion: IgA nephropathy in peripheral blood regulatory T cells level increased compared with normal person,and traditional Chinese medicine syndrome differentiation and treatment could treat of IgA nephropathy effectively possibly by reducing peripheral blood regulatory T cell level.