CONTROL STUDY BETWEEN RISPERIDONE ORAL SOLUTION AND OLANZAPINE FOR ALCOHOL-INDUCED MENTAL DISORDER

Objective:To compare the efficacy and safety of risperidone oral solution and olanzapine in the treatment of alcohol-induced mental disorder.Methods:Sixty-eight male patients with alcohol-induced mental disorder were randomly divided into risperidone oral solution group and olanzapine group.Clinical effect was evaluated by Positive and Negative Syndrome Scale(PANSS),and the adverse drug reactions were assessed with Treatment Emergent Symptom Scale(TESS).Results:No significant differences were observed in the clinical effect of the two groups.The main side effect experienced by the olanzapine group was body weight gain,while the resperidone oral solution group showed extrapyramidal responses.Conclusion:Both olanzapine and risperidone oral solution are safe and effective for the treatment of alcohol-induced mental disorder,and can be clinically selected according to patients' tolerance of the side effects.