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The expression of CXCL12 and VEGF in preeclampsia

Zhong Shao

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Abstract

Objective:To study the expression of CXC12 and VEGF in placenta of normal pregnancy and pre-eclampsia, and the level of CXC12 and VEGF in the correspond serum, to understand the mechanism of CXC12 and VEGF in pre-eclampsia.Methods:Use the immunohistochemistry to determine the intensity of CXC12 and VEGF staining in placenta of normal pregnancy and pre-eclampsia (10, 12 cases during superimposed pre-eclampsia and 18 cases of normal pregnant women) and examine the serum level by ELISA.Results:CXC12 and VEGF proteins were observed in trophoblast in the placentas. Expression of CXC12 and VEGF decreased dramatically in the placentas of severe superimposed pre-eclampsia (P0.01). The same diversification occurred in the serum.Conclusion:CXCL12 and VEGF may be concerned with the onset of pre-eclampsia.

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What this paper is about

Objective:To study the expression of CXC12 and VEGF in placenta of normal pregnancy and pre-eclampsia, and the level of CXC12 and VEGF in the correspond serum, to understand the mechanism of CXC12 and VEGF in pre-eclampsia.Methods:Use the immunohistochemistry to determine the intensity of CXC12 and VEGF staining in placenta of normal pregnancy and pre-eclampsia (10, 12 cases during superimposed pre-eclampsia and 18 cases of normal pregnant women) and examine the serum level by ELISA.Results:CXC12 and VEGF proteins were observed in trophoblast in the placentas. Expression of CXC12 and VEGF decreased dramatically in the placentas of severe superimposed pre-eclampsia (P0.01). The same diversification occurred in the serum.Conclusion:CXCL12 and VEGF may be concerned with the onset of pre-eclampsia.

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Available abstract

Objective:To study the expression of CXC12 and VEGF in placenta of normal pregnancy and pre-eclampsia, and the level of CXC12 and VEGF in the correspond serum, to understand the mechanism of CXC12 and VEGF in pre-eclampsia.Methods:Use the immunohistochemistry to determine the intensity of CXC12 and VEGF staining in placenta of normal pregnancy and pre-eclampsia (10, 12 cases during superimposed pre-eclampsia and 18 cases of normal pregnant women) and examine the serum level by ELISA.Results:CXC12 and VEGF proteins were observed in trophoblast in the placentas. Expression of CXC12 and VEGF decreased dramatically in the placentas of severe superimposed pre-eclampsia (P0.01). The same diversification occurred in the serum.Conclusion:CXCL12 and VEGF may be concerned with the onset of pre-eclampsia.

Key concepts: Medicine, Eclampsia, Trophoblast, Placenta, VEGF receptors, Preeclampsia, Immunohistochemistry, Pregnancy

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