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2007•Journal of Shantou University Medical CollegeRequires access

Suitable Dosage of Reserpine for Animal Model of Depression

XU Chong-tao

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Abstract

Objective:To establish the suitable dosage of reserpine for animal model of depression,and to observe the different dosage of reserpine on locomotion activity in rats.Methods:Rats were randomly assigned into test group[intraperitoneally administrated by different dosage of reserpine(2、4、6 mg/kg)]and control group(injected the same volume of solvent).The locomotion activity was tested by open field test one hour after injection.Results:Reserpine(2、4、6 mg/kg)could cause depressive behavior,4 mg/kg group was different from that of 2 mg/kg group(P0.05),but there was no difference between 4 and 6 mg/kg groups.The behavior change lasted 48 ～ 72 hours.Conclusion:Reserpine may result in the depressive behavior of rat,4 mg/kg is the suitable dosage for animal model of depression.

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What this paper is about

Objective:To establish the suitable dosage of reserpine for animal model of depression,and to observe the different dosage of reserpine on locomotion activity in rats.Methods:Rats were randomly assigned into test group[intraperitoneally administrated by different dosage of reserpine(2、4、6 mg/kg)]and control group(injected the same volume of solvent).The locomotion activity was tested by open field test one hour after injection.Results:Reserpine(2、4、6 mg/kg)could cause depressive behavior,4 mg/kg group was different from that of 2 mg/kg group(P0.05),but there was no difference between 4 and 6 mg/kg groups.The behavior change lasted 48 ～ 72 hours.Conclusion:Reserpine may result in the depressive behavior of rat,4 mg/kg is the suitable dosage for animal model of depression.

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Available abstract

Objective:To establish the suitable dosage of reserpine for animal model of depression,and to observe the different dosage of reserpine on locomotion activity in rats.Methods:Rats were randomly assigned into test group[intraperitoneally administrated by different dosage of reserpine(2、4、6 mg/kg)]and control group(injected the same volume of solvent).The locomotion activity was tested by open field test one hour after injection.Results:Reserpine(2、4、6 mg/kg)could cause depressive behavior,4 mg/kg group was different from that of 2 mg/kg group(P0.05),but there was no difference between 4 and 6 mg/kg groups.The behavior change lasted 48 ～ 72 hours.Conclusion:Reserpine may result in the depressive behavior of rat,4 mg/kg is the suitable dosage for animal model of depression.

Key concepts: Reserpine, Animal model, Open field, Behavioural despair test, Depression (economics), Pharmacology, Chemistry, Medicine

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