Antidepressant activity of alprazolam in a reserpine‐induced model of depression

Abstract The effect of chronic (14–21 day) administration of reserpine (0.1 mg/kg/day), imipramine (10 mg/kg/day), alprazolam (5, 10 and 15 mg/kg/day), and diazepam (10 and 30 mg/kg/day) on beta‐adrenergic receptors in the cerebral cortex and body weight has been reported in this study. Chronic treatment with both imipramine and alprazolam significantly blocked reserpine‐induced increases in beta‐adrenergic receptors and loss in body weight. However, diazepam under similar conditions had no significant effect.