Analysis of Conservative Motif Features of the Protein Superfamilies in All α Class

Four representative protein suprefamilies are chosen from all α protein class.The sequence and structure motifs are extracted from the sequences with identity less than 40% and 25%.By discussing their different function features,the results indicate that the known function motifs are relatively single in Cytochrome C superfamily and EF-hand superfamily.Many types of sequence motifs responding to structural motif are HTH and wHTH in Homeodomain-Like and the Winged helix DNA-binding domain superfamily,respectively.By calculating and comparing motif position,some important regularities of the position distribution are obtained.The distance between motifs and C(or N) terminal of sequence is conservative for motif whether from function or statistic significance.These correlated regularities will have some important help for identifying different protein superfamilies and the protein domains.