2002•中国科学通报：英文版Requires access
Identification of protein superfamily from structure-based sequence motif
Jingfei, Huang, Ciquan, Liu
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Abstract
The structure-based sequence motif of the distant proteins in evolution, protein tyrosine phosphatases (PTP) I and Ⅱ superfamilies, as an example, has been defined by the structural comparison, structure-based sequence alignment and analyses on substitution patterns of residues in common sequence conserved regions. And the phosphatases I and Ⅱ can be correctly identified together by the structure-based PTP sequence motif from SWISS-PROT and TrEBML databases. The results show that the correct rates of identification are over 98%. This is the first time to identify PTP I and Ⅱ together by this motif.