2008•Liaoning Yixueyuan xuebaoRequires access
Effects of Carvedilol on Vascular Endothelium Function and Heart Function of Patients with Chronic Heart Failure
Weijiang Zhang
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Abstract
Objective To observe the effects of carvedilol on vascular endothelium function and heart function of patients with chronic heart failure(CHF). Methods 74 cases with CHF were divided randomly into the normal group (n=37)and the carvedilol group(n=37). Digitalis, diuretic and angiotensin-converting enzyme(ACE) were taken into normal group, while carvedilol were taken into the carvedilol group; the dose of carvedilol was gradually increased within the tolerance range. The vascular endothelium function and heart function were observed after six-month period. Results The vascular endothelium function and heart function of the carvedilol group were improved remarkably compared with that of the normal group. There appeared no side effect and no impairment of liver and renal function in carvedilol group.Conclusions Applying carvedilol could enhance the curative effect of CHF patients.