Expression and clinical significance of 14-3-3σ,p73α protein in infiltrating breast cancer

Objective To investigate the effects of 14-3-3σ and p73α protein expression in the occurrence and development of infiltrating breast cancer.Methods The expression of 14-3-3σ and p73α protein were measured in 94 infiltrating breast cancers tissues(invasive carcinoma group),15 intraductal carcinoma in situ(carcinoma in situ group),15 untypical ductal epithelial hyperplasia(untypical hyperplasia group),15 intraductal papilloma(papilloma group),20 hyperplastic disease of the breast(hyperplastic group)and 10 peficancerous tissues(peficancerous tissues group) which resected in our hospital by immunohistochemistry PV two-step method,analyzed the correlation of both indexes and which between clinical pathologic features.Results The positive rate of 14-3-3σ protein in invasive carcinoma group was significantly lower than that in the other groups,and the positive rate of p73α protein was significantly higher(all P0.05).The expression of 14-3-3σ protein was significantly correlated with histological grade,TNM stage,axillary lymph node metastasis and HER-2 expression,the expression of p73α protein was significantly correlated with axillary lymph node metastasis,histological grade,TNM stage,ER and PR expression.And there were negative correlations between the expression of 14-3-3σ and p73α protein.Conclusion The protein of 14-3-3σ and p73α may be related to the development of infiltrating breast cancer,and combined detection of which may provide reference for early diagnosis and treatment of breast cancer.