2004•Chinese Journal of MisdiagnosticsRequires access
Study in the Relationships between Expressions of E-Cadherin and PCNA in Gastric Carcinoma
Liu Mao-ron
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Abstract
Objective:To investigate the relationships between expressions of E-cadherin and PCNA in gastric car-
cinoma. Methods:Expressions of E-cadherin and PCNA in paraffin imbedded specimens of 60 gastric carcinoma were de-
tected by immunohistochemistry. Results: 39 (65%) of the 60 gastric carcinoma showed reduced E-cadherin expression,
and 21(35%) showed normal E-cadherin expression. 30(50%) of the 60 gastric carcinorna showed high PCNA expres-
sion, and 30(50%) showed low PCNA expression. Significant correlation was found between E-cadherin and PCNA ex-
pressions (P0.05). Conclusions: Normal E-cadherin expression mighthave inhibitive effect on cell proliferation of gas-
tric carcinoma, while reduced E-cadherin expression could promote cell proliferation, but the effection was incomplete.