2006•Fine Chemical IntermediatesRequires access
Synthesis of 4-Chlorobutyryl Chloride
Duan Hai-long
Open publisher page 1 citations
Abstract
The synthesis of 4-chlorobutyryl chloride was described using γ-butyroctone as material,anhydrous zinc chloride as the catalyst and thionyl chloride as chloridum.The reaction principle is expounded,and the main factors affecting the reaction are investigated.Optimal conditions were obtained as follow:reaction temperature is 55℃,reaction time 22 h and percent amount of catalyst 3%~5%.The yield of the product is 82.7% under the optimal conditions.